Department of Genetics
Bioinformatics and Computational Biology
Program for Precision Medicine in Health Care
The Wang lab integrates advanced sequencing and high-performance computational genomics to enable precision medicine in diverse healthcare settings and populations. Our main focus is development of technologies to support faster, more accurate, and resource-appropriate molecular diagnostics for cancer and microbial pathogens.
As a part of UNC RAISE, a primary goal is the development of sequencing and computational technologies to enable precision cancer diagnostics in low-resource settings
Comprehensive clinical diagnosis of childhood cancers relies on multiple costly and time-consuming techniques such as immunohistochemistry (IHC), flow cytometry, cytogenetics, fluorescence in situ hybridization (FISH), targeted PCR panels, and microarrays. Nanopore RNA-sequencing represents a potential alternative to flow cytometry, IHC, and cytogenetic approaches in low-resource settings. Clinically-relevant characterization, including cell lineage and genomic subtype, are made from low-coverage transcriptome profiling via a machine learning classifier.
Wang et al, 2022Single-molecule sequencing of metagenomes produces more specific taxonomic and genic characterization than standard NGS, but challenges remain due to relatively low throughput and high error rate, particularly from host-associated microbial communities. We have developed novel sequencing and informatics approaches to increase throughput and classification accuracy in both synthetic and human tissue-associated microbiota.
Wang et al, 2021
Jeremy Wang, Ph.D.
Assistant Professor
Department of Genetics
Program for Precision Medicine in Health Care
Center for Gastrointestinal Biology and Disease
John Lin
Ph.D. student
Curriculum for Bioinformatics and Computational Biology
Kofi Opoku, M.D., M.P.H.
Research Associate
Julie Geyer, Ph.D.
Postdoctoral Research Associate
Ashley Merrills
Undergraduate Researcher
Graduate students are admitted through the Biological & Biomedical Sciences Program, through which you may join any number of labs, including ours.
Prospective postdocs should email their CV to [ jeremy @ unc ⋅ edu ].